Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Oct 23;18(12):100.
doi: 10.1007/s11910-018-0904-9.

Serotonin Selective Reuptake Inhibitors (SSRIs) and Stroke

Affiliations
Review

Serotonin Selective Reuptake Inhibitors (SSRIs) and Stroke

F Chollet et al. Curr Neurol Neurosci Rep. .

Abstract

Purpose of review: The interest in SSRIs after stroke has increased in the past few years, with better knowledge of post-stroke depression and with the demonstrated capacity of some SSRIs to act on the functional recovery of non-depressed subjects.

Recent findings: Arguments for the action of SSRIs in favour of post-stroke neurological function recovery have improved through new elements: basic science and preclinical data, positive clinical trials and repeated series of stroke patient meta-analysis, and confirmation of favourable safety conditions in post-stroke patients. Global coherence is appearing, showing that SSRIs improve stroke recovery in non-depressed patients when given for 3 months after the stroke, with highly favourable safety conditions and a favourable benefit/risk ratio. Large series are still needed.

Keywords: Brain plasticity; Ischaemic stroke; Neuroprotection; Post-stroke depression; Recovery from stroke; SSRIs.

Similar articles

See all similar articles

Cited by 3 articles

References

    1. Sci Rep. 2017 Nov 28;7(1):16466 - PubMed
    1. J Neurol Neurosurg Psychiatry. 2001 Aug;71(2):258-61 - PubMed
    1. Stroke. 2006 Jan;37(1):156-61 - PubMed
    1. Am J Cardiol. 2017 Feb 15;119(4):651-657 - PubMed
    1. Stroke. 1997 Dec;28(12):2518-27 - PubMed

MeSH terms

Substances

LinkOut - more resources

Feedback