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. 2018 Oct 23;18(12):100.
doi: 10.1007/s11910-018-0904-9.

Serotonin Selective Reuptake Inhibitors (SSRIs) and Stroke


Serotonin Selective Reuptake Inhibitors (SSRIs) and Stroke

F Chollet et al. Curr Neurol Neurosci Rep. .


Purpose of review: The interest in SSRIs after stroke has increased in the past few years, with better knowledge of post-stroke depression and with the demonstrated capacity of some SSRIs to act on the functional recovery of non-depressed subjects.

Recent findings: Arguments for the action of SSRIs in favour of post-stroke neurological function recovery have improved through new elements: basic science and preclinical data, positive clinical trials and repeated series of stroke patient meta-analysis, and confirmation of favourable safety conditions in post-stroke patients. Global coherence is appearing, showing that SSRIs improve stroke recovery in non-depressed patients when given for 3 months after the stroke, with highly favourable safety conditions and a favourable benefit/risk ratio. Large series are still needed.

Keywords: Brain plasticity; Ischaemic stroke; Neuroprotection; Post-stroke depression; Recovery from stroke; SSRIs.

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