Spermidine reduces cancer-related mortality in humans

Federico Pietrocola; Francesca Castoldi; Oliver Kepp; Didac Carmona-Gutierrez; Frank Madeo; Guido Kroemer

doi:10.1080/15548627.2018.1539592

Spermidine reduces cancer-related mortality in humans

Autophagy. 2019 Feb;15(2):362-365. doi: 10.1080/15548627.2018.1539592. Epub 2018 Oct 29.

Authors

Federico Pietrocola^{1

2}, Francesca Castoldi^{2

3

4

5

6

7

8}, Oliver Kepp^{2

3

4

5

6

7

8}, Didac Carmona-Gutierrez^{9

10}, Frank Madeo^{9

10}, Guido Kroemer^{2

3

4

5

6

7

8

11

12}

Affiliations

¹ a Institute for Research in Biomedicine , Barcelona , Spain.
² b INSERM, U1138 , Paris , France.
³ c Gustave Roussy Cancer Campus , Villejuif , France.
⁴ d Equipe 11 labellisée par la Ligue Nationale contre le Cancer , Centre de Recherche des Cordeliers , Paris , France.
⁵ e Université Paris Descartes/Paris V, Sorbonne Paris Cité , Paris , France.
⁶ f Metabolomics and Cell Biology Platforms , Gustave Roussy Cancer Campus , Villejuif , France.
⁷ g Université Pierre et Marie Curie , Paris , France.
⁸ h Faculté de Medecine; Kremlin-Bicetre , Université Paris-Sud/Paris-Saclay , Kremlin Bicêtre , France.
⁹ i Institute of Molecular Biosciences , University of Graz, NAWI Graz , Graz , Austria.
¹⁰ j BioTechMed Graz , Graz , Austria.
¹¹ k Pôle de Biologie, Hôpital Européen Georges Pompidou , AP-HP , Paris , France.
¹² l Karolinska Institute, Department of Women's and Children's Health , Karolinska University Hospital , Stockholm , Sweden.

Abstract

A recent prospective epidemiological study suggested that an increase in the nutritional uptake of the natural polyamine spermidine is associated with reduced overall and cancer-specific mortality. Here, we speculate through which mechanisms spermidine might exert such oncopreventive effects. Abbreviations: ACLY, ATP citrate lyase; ATG, autophagy-related gene; CoA, coenzyme A; NSCLC, non-small cell lung cancer.

Keywords: Aspirin; Autophagy; aging; immunosurveillance; inflammation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / therapeutic use
Humans
Mice
Neoplasms / drug therapy*
Neoplasms / mortality*
Spermidine / therapeutic use*

Substances

Antineoplastic Agents
Spermidine

Grants and funding

This work was supported by the Ligue contre le Cancer (équipe labellisée); Agence National de la Recherche (ANR); ERA-Net for Research on Rare Diseases; Association pour la recherche sur le cancer (ARC); Cancéropôle Ile-de-France; Fondation pour la Recherche Médicale (FRM); European Commission (ArtForce); European Research Area Network on Cardiovascular Diseases (ERA-CVD, MINOTAUR); European Research Council (ERC); Fondation Carrefour; Institut National du Cancer (INCa); Inserm (HTE); Institut Universitaire de France; LeDucq Foundation; LabEx Immuno-Oncology; RHU Torino Lumière; the Seerave Foundation; SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE); SIRIC Cancer Research and Personalized Medicine (CARPEM); Paris Alliance of Cancer Research Institutes (PACRI); Austrian Science Fund FWF (Austria); [P23490-B20]; [P29262]; [P24381]; [P29203]; [P27893]; [I1000].