Spermidine reduces cancer-related mortality in humans

Autophagy. 2019 Feb;15(2):362-365. doi: 10.1080/15548627.2018.1539592. Epub 2018 Oct 29.


A recent prospective epidemiological study suggested that an increase in the nutritional uptake of the natural polyamine spermidine is associated with reduced overall and cancer-specific mortality. Here, we speculate through which mechanisms spermidine might exert such oncopreventive effects. Abbreviations: ACLY, ATP citrate lyase; ATG, autophagy-related gene; CoA, coenzyme A; NSCLC, non-small cell lung cancer.

Keywords: Aspirin; Autophagy; aging; immunosurveillance; inflammation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / therapeutic use
  • Humans
  • Mice
  • Neoplasms / drug therapy*
  • Neoplasms / mortality*
  • Spermidine / therapeutic use*


  • Antineoplastic Agents
  • Spermidine

Grants and funding

This work was supported by the Ligue contre le Cancer (équipe labellisée); Agence National de la Recherche (ANR); ERA-Net for Research on Rare Diseases; Association pour la recherche sur le cancer (ARC); Cancéropôle Ile-de-France; Fondation pour la Recherche Médicale (FRM); European Commission (ArtForce); European Research Area Network on Cardiovascular Diseases (ERA-CVD, MINOTAUR); European Research Council (ERC); Fondation Carrefour; Institut National du Cancer (INCa); Inserm (HTE); Institut Universitaire de France; LeDucq Foundation; LabEx Immuno-Oncology; RHU Torino Lumière; the Seerave Foundation; SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE); SIRIC Cancer Research and Personalized Medicine (CARPEM); Paris Alliance of Cancer Research Institutes (PACRI); Austrian Science Fund FWF (Austria); [P23490-B20]; [P29262]; [P24381]; [P29203]; [P27893]; [I1000].