Epigenetic Modifications in Cardiovascular Aging and Diseases

Circ Res. 2018 Sep 14;123(7):773-786. doi: 10.1161/CIRCRESAHA.118.312497.


Aging is associated with a progressive decline in cardiovascular structure and function. Accumulating evidence links cardiovascular aging to epigenetic alterations encompassing a complex interplay of DNA methylation, histone posttranslational modifications, and dynamic nucleosome occupancy governed by numerous epigenetic factors. Advances in genomics technology have led to a profound understanding of chromatin reorganization in both cardiovascular aging and diseases. This review summarizes recent discoveries in epigenetic mechanisms involved in cardiovascular aging and diseases and discusses potential therapeutic strategies to retard cardiovascular aging and conquer related diseases through the rejuvenation of epigenetic signatures to a young state.

Keywords: aging; disease; epigenomics; genomics; histones.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Age Factors
  • Aging / genetics*
  • Aging / metabolism
  • Aging / pathology
  • Animals
  • Cardiovascular Diseases / genetics*
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / pathology
  • Cardiovascular Diseases / physiopathology
  • Cardiovascular System* / metabolism
  • Cardiovascular System* / pathology
  • Cardiovascular System* / physiopathology
  • Chromatin Assembly and Disassembly
  • DNA Methylation*
  • Epigenesis, Genetic*
  • Gene Expression Regulation
  • Genetic Predisposition to Disease
  • Health Status
  • Healthy Aging
  • Humans
  • Life Expectancy
  • Phenotype
  • RNA, Untranslated / genetics
  • RNA, Untranslated / metabolism
  • Risk Factors
  • Signal Transduction


  • RNA, Untranslated