Myeloma MRD by deep sequencing from circulating tumor DNA does not correlate with results obtained in the bone marrow

Blood Adv. 2018 Nov 13;2(21):2811-2813. doi: 10.1182/bloodadvances.2018025197.

Abstract

There is no correlation between ctDNA and bone marrow for MRD by NGS using only immunoglobulin gene rearrangements in myeloma patients.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor / genetics
  • Biomarkers, Tumor / metabolism
  • Bone Marrow / metabolism*
  • Circulating Tumor DNA / chemistry*
  • Circulating Tumor DNA / metabolism
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Multiple Myeloma / diagnosis*
  • Multiple Myeloma / metabolism
  • Neoplasm, Residual
  • Plasma Cells / metabolism
  • Sequence Analysis, DNA
  • V(D)J Recombination / genetics

Substances

  • Biomarkers, Tumor
  • Circulating Tumor DNA