Neuronal antinuclear antibody (anti-Hu) in paraneoplastic encephalomyelitis simulating acute polyneuritis

Acta Neurol Scand. 1987 Apr;75(4):249-52. doi: 10.1111/j.1600-0404.1987.tb07928.x.


A patient with paraneoplastic encephalomyelitis (PEM) and small cell lung cancer had a clinical presentation of acute polyneuritis. The patient had an antibody (anti-Hu) restricted to nuclei of neurons identical to that reported in patients with subacute sensory neuronopathy and lung cancer. This finding further supports the hypothesis that PEM and subacute sensory neuronopathy are closely related disorders of autoimmune origin. PEM should be considered in patients with small cell lung cancer and clinical features limited to the peripheral nervous system.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Antinuclear / analysis*
  • Carcinoma, Small Cell / immunology
  • Diagnosis, Differential
  • Encephalomyelitis / diagnosis
  • Encephalomyelitis / immunology*
  • Ganglia, Spinal / pathology
  • Humans
  • Lung Neoplasms / immunology
  • Male
  • Middle Aged
  • Neurons / immunology*
  • Paraneoplastic Syndromes / diagnosis
  • Paraneoplastic Syndromes / immunology*
  • Polyneuropathies / diagnosis*
  • Spinal Cord / pathology


  • Antibodies, Antinuclear