Depression and Its Association with Health-Related Quality of Life in Postmenopausal Women in Korea

Int J Environ Res Public Health. 2018 Oct 23;15(11):2327. doi: 10.3390/ijerph15112327.


Menopause is associated with depressive symptoms that can significantly affect a woman's quality of life. The objective of this study was to evaluate the association between depression and health-related quality of life (HRQoL) in postmenopausal women. In this cross-sectional descriptive study, participants (n = 3860) were selected from the 2013⁻2015 Korea National Health and Nutrition Examination Survey (KNHANES). The sociodemographic characteristics, medical history of depression, and EQ-5D scores of the participants were obtained from the KNHANES dataset. Age, educational level, and income were associated with HRQoL in these participants. Moreover, depression exerted a considerable influence on HRQoL in postmenopausal women. The adjusted odds ratios in participants with depression for the EQ-5D dimensions were as follows: 5.52 (95% CI = 4.04⁻7.55, p < 0.001) for anxiety/depression, 3.86 (95% CI = 2.78⁻5.36, p < 0.001) for usual activities, and 2.52 (95% CI = 1.68⁻3.78, p < 0.001) for self-care. Our findings suggest a strong association between depression and HRQoL. Hence, preventing the onset or exacerbation of depression may significantly improve quality of life in postmenopausal women.

Keywords: EQ-5D; demographic factor; depression; health-related quality of life.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cross-Sectional Studies
  • Depression / epidemiology*
  • Female
  • Health Surveys
  • Humans
  • Male
  • Middle Aged
  • Postmenopause / psychology*
  • Quality of Life*
  • Republic of Korea / epidemiology
  • Socioeconomic Factors