Keywords: Clostridium difficile; Cutibacterium acnes; Enterococcus; Mycobacterium tuberculosis; amphotericin B; antibiotic alternatives; antibiotic duration; fungal PJI; gram-negative PJI; methicillin-resistant Staphylococcus epidermidis; minimum biofilm bactericidal concentration; minimum biofilm inhibitory concentration; minimum inhibitory concentration; polymicrobial periprosthetic joint infection; resistant microorganisms; rifampicin resistance; treatment.