A review of existing and new methods of bronchoscopic diagnosis of lung cancer

Respir Investig. 2019 Jan;57(1):3-8. doi: 10.1016/j.resinv.2018.08.004. Epub 2018 Oct 22.


Bronchoscopy is one of the main techniques used for sampling lung tumor biopsies. In recent years, a large number of tumor specimens have been required to determine the best chemotherapy regimen for each patient; this personalized approach is known as precision medicine. In this review, radial endobronchial ultrasound; bronchoscopic navigation systems, including virtual bronchoscopic navigation and electromagnetic navigation; ultrathin bronchoscope,; and endobronchial ultrasound-guided transbronchial needle aspiration are highlighted as techniques used to increase the diagnostic yield. Personalized therapy includes tests for analysis of epidermal growth factor mutations, anaplastic lymphoma kinase or ROS proto-oncogene 1 fusion gene, and programmed death ligand 1 expression. In cryobiopsy, a relatively large amount of tissue is collected from endobronchial lung cancer and peripheral pulmonary lesions, and it is a promising technique for analyzing these tissues using molecular tests.

Keywords: Bronchoscopy; Cryobiopsy; Lung cancer Diagnosis; Pathology; Ultrasound.

Publication types

  • Review

MeSH terms

  • Anaplastic Lymphoma Kinase / genetics
  • Anaplastic Lymphoma Kinase / metabolism
  • Biomarkers, Tumor / genetics
  • Biomarkers, Tumor / metabolism
  • Biopsy, Fine-Needle
  • Bronchoscopy* / methods
  • Epidermal Growth Factor / genetics
  • Gene Expression
  • Humans
  • Image-Guided Biopsy
  • Lung Neoplasms / diagnosis*
  • Lung Neoplasms / pathology*
  • Mutation
  • Precision Medicine
  • Proto-Oncogene Mas
  • Ultrasonography


  • Biomarkers, Tumor
  • MAS1 protein, human
  • Proto-Oncogene Mas
  • Epidermal Growth Factor
  • Anaplastic Lymphoma Kinase