Ginger (Zingiber officinale Rosc.) Ameliorated Metabolic and Inflammatory Dysfunction Induced by High-Refined Carbohydrate-Containing Diet in Mice

J Med Food. 2019 Jan;22(1):38-45. doi: 10.1089/jmf.2018.0062. Epub 2018 Oct 26.


This study aimed to evaluate the effects and the mechanisms of ginger extract intake in the adiposity gain, metabolic and inflammatory disturbances induced by a high-refined carbohydrate (HC) diet in mice. Ginger extract at doses of 200, 600, and 1800 mg/kg was supplemented in the daily food of obese Balb/c mice during an 8-week experiment. Our findings indicate that consumption of high doses of ginger extracts prevents the increase of adiposity induced by HC diet, improves lipid profile, and promotes decrease of inflammatory markers in mice. We showed that ginger addition to HC diet leads to decrease in the recruitment of cells visualized in vivo in the microvasculature of adipose tissue, decrease of inflammatory cytokines, and increase of adiponectin serum levels. These results indicate that the consumption of ginger decreases the negative metabolic consequences induced by HC diet.

MeSH terms

  • Adiponectin / blood
  • Adiposity
  • Animals
  • Cytokines / blood
  • Diet*
  • Dietary Carbohydrates / administration & dosage
  • Dietary Carbohydrates / pharmacology*
  • Ginger*
  • Inflammation / blood
  • Inflammation / etiology
  • Inflammation / prevention & control*
  • Lipids / blood
  • Male
  • Mice, Inbred BALB C
  • Mice, Obese
  • Obesity / blood
  • Obesity / complications
  • Obesity / drug therapy*
  • Phytotherapy*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*


  • Adiponectin
  • Cytokines
  • Dietary Carbohydrates
  • Lipids
  • Plant Extracts