Initial assessment of tumor-associated antigen CA-125 in patients with ovarian, cervical, and testicular tumors

Clin Chem. 1987 Jul;33(7):1124-5.


Serum CA-125, a glycoprotein antigen, has been measured in serum of patients with ovarian cancer, cervical cancer, or nonseminomatous germ-cell tumor of testis. Increased concentrations were found in 21 of 27 patients with epithelial ovarian cancer and two of three patients with ovarian teratoma. Changes in CA-125 concentrations in serum during chemotherapy mirrored the progress of the disease as assessed by clinical and radiological evidence. Although CA-125 provides no real asset for diagnosis, it should have value as a marker for monitoring response to chemotherapy.

MeSH terms

  • Adult
  • Antigens, Neoplasm / analysis*
  • Antigens, Surface
  • Antigens, Tumor-Associated, Carbohydrate
  • Carboplatin
  • Carcinoma / drug therapy
  • Carcinoma / immunology
  • Female
  • Humans
  • Male
  • Neoplasms, Germ Cell and Embryonal / drug therapy
  • Neoplasms, Germ Cell and Embryonal / immunology
  • Organoplatinum Compounds / therapeutic use
  • Ovarian Neoplasms / drug therapy
  • Ovarian Neoplasms / immunology*
  • Teratoma / drug therapy
  • Teratoma / immunology
  • Testicular Neoplasms / drug therapy
  • Testicular Neoplasms / immunology*
  • Uterine Cervical Neoplasms / drug therapy
  • Uterine Cervical Neoplasms / immunology*


  • Antigens, Neoplasm
  • Antigens, Surface
  • Antigens, Tumor-Associated, Carbohydrate
  • Organoplatinum Compounds
  • Carboplatin