Increased Discrimination of Treponema pallidum Strains by Subtyping With a 4-Component System Incorporating a Mononucleotide Tandem Repeat in rpsA

Sex Transm Dis. 2019 Apr;46(4):e42-e45. doi: 10.1097/OLQ.0000000000000935.


A guanine mononucleotide repeat in the rpsA (tp0279) gene was evaluated for improved strain discrimination using 72 Treponema pallidum-positive specimens. The tandem repeat combined with the enhanced Centers for Disease Control and Prevention typing system resulted in increased discrimination and should be useful for molecular epidemiologic studies on syphilis especially in outbreaks and among men who have sex with men.

Publication types

  • Evaluation Study

MeSH terms

  • DNA, Bacterial / genetics*
  • Genotype
  • Homosexuality, Male
  • Humans
  • Male
  • Molecular Typing / methods*
  • Point Mutation
  • RNA, Ribosomal, 23S / genetics
  • Syphilis / microbiology*
  • Tandem Repeat Sequences*
  • Treponema pallidum / classification*


  • DNA, Bacterial
  • RNA, Ribosomal, 23S