Integrating thin film microfluidics in developing a concise synthesis of DGJNAc: A potent inhibitor of α-N-acetylgalctosaminidases

Siobhán S Wills; Colin L Raston; Keith A Stubbs

doi:10.1016/j.bmcl.2018.10.015

Integrating thin film microfluidics in developing a concise synthesis of DGJNAc: A potent inhibitor of α-N-acetylgalctosaminidases

Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3748-3751. doi: 10.1016/j.bmcl.2018.10.015. Epub 2018 Oct 11.

Authors

Siobhán S Wills¹, Colin L Raston², Keith A Stubbs³

Affiliations

¹ School of Molecular Sciences, University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia.
² Institute for Nanoscale Science and Technology, College of Science and Engineering, Flinders University, Sturt Road, Bedford Park, SA 5042, Australia.
³ School of Molecular Sciences, University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia. Electronic address: keith.stubbs@uwa.edu.au.

PMID: 30366618
DOI: 10.1016/j.bmcl.2018.10.015

Abstract

A simple synthesis, which utilizes a thin film microfluidic reactor for a problematic step, of a potent inhibitor of α-N-acetylhexosaminidases, DGJNAc, has been developed.

Keywords: Flow chemistry; Glycosidases; Iminosugars; Inhibitors; Thin film microfluidics.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

1-Deoxynojirimycin / analogs & derivatives*
1-Deoxynojirimycin / chemical synthesis
Chemistry Techniques, Synthetic / economics
Chemistry Techniques, Synthetic / instrumentation*
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / chemistry
Hexosaminidases / antagonists & inhibitors*
Humans
Lab-On-A-Chip Devices* / economics

Substances

Enzyme Inhibitors
1-Deoxynojirimycin
Hexosaminidases