Whole-Genome Duplication and Yeast's Fruitful Way of Life

Trends Genet. 2019 Jan;35(1):42-54. doi: 10.1016/j.tig.2018.09.008. Epub 2018 Oct 23.


Studies on the fate of Saccharomyces cerevisiae paralogous gene pairs that arose through a whole-genome duplication event have shown diversification of retained duplicated genes. Paralogous functional specialization often results in improved function and/or novel function that could contribute to the adaptation of the organism to a new lifestyle. Here, we analyze and discuss particular case studies of paralogous functional diversification that could have played a role in the acquisition of yeast fermentative metabolism.

Keywords: Saccharomyces cerevisiae; fermentative metabolism; functional diversification; paralogous genes; whole-genome duplication.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptation, Physiological / genetics
  • Evolution, Molecular*
  • Gene Duplication / genetics
  • Genome, Fungal / genetics*
  • Phylogeny
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / metabolism