Facial Motor and Non-Motor Disabilities in Patients With Central Facial Paresis: A Prospective Cohort Study

J Neurol. 2019 Jan;266(1):46-56. doi: 10.1007/s00415-018-9099-x. Epub 2018 Oct 26.

Abstract

Although central facial paresis (CFP) is a major symptom of stroke, there is a lack of studies on the motor and non-motor disabilities in stroke patients. A prospective cohort study was performed at admission for inpatient rehabilitation and discharge of post-stroke phase of 112 patients (44% female, median age: 64 years, median Barthel index: 70) with CFP. Motor function was evaluated using House-Brackmann grading, Sunnybrook grading and Stennert Index. Automated action unit (AU) analysis was performed to analyze mimic function in detail. Non-motor function was assessed using the Facial Disability Index (FDI) and the Facial Clinimetric Evaluation (FaCE). Median interval from stroke to rehabilitation was 21 days. Rehabilitation lasted 20 days. House-Brackmann grading was ≥ grade III for 79% at admission. AU activation in the lower face was significantly lower in patients with right hemispheric infarction compared to left hemispheric infarction (all p < 0.05). Median total FDI and FaCE score were 46.5 and 69, respectively. Facial grading and FDI/FaCE scores improved during inpatient rehabilitation (all p < 0.05). There was a significant increase of the activation of AU12 (Zygomaticus major muscle), AU13 (Levator anguli oris muscle), and AU24 (Orbicularis oris muscle) during inpatient rehabilitation (all p < 0.05). Multivariate analysis revealed that activation of AU10 (Levator labii superioris), AU12, AU17 (Depressor labii), and AU 38 (Nasalis) were independent predictors for better quality of life. These results demonstrate that CFP has a significant impact on patient's quality of life. Therapy of CFP with focus on specific AUs should be part of post-stroke rehabilitation.

Keywords: Action units; Central facial paresis; Facial Clinimetric Evaluation Scale; Facial Disability Index; Facial grading; Quality of life.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Disability Evaluation
  • Facial Expression
  • Facial Muscles / physiopathology
  • Facial Paralysis / diagnosis
  • Facial Paralysis / physiopathology*
  • Facial Paralysis / psychology
  • Facial Paralysis / rehabilitation*
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Motor Activity
  • Pattern Recognition, Automated
  • Prospective Studies
  • Quality of Life
  • Severity of Illness Index
  • Stroke / complications
  • Stroke / physiopathology
  • Stroke / psychology
  • Stroke Rehabilitation

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