Adipose-derived mesenchymal stem cells treatments for fibroblasts of fibrotic scar via downregulating TGF-β1 and Notch-1 expression enhanced by photobiomodulation therapy

Lasers Med Sci. 2019 Feb;34(1):1-10. doi: 10.1007/s10103-018-2567-9. Epub 2018 Oct 26.

Authors

Bing Han¹, Jincai Fan², Liqiang Liu¹, Jia Tian¹, Cheng Gan¹, Zengjie Yang¹, Hu Jiao¹, Tiran Zhang¹, Zheng Liu¹, Hua Zhang¹

Affiliations

¹ Ninth Department of Plastic Surgery, Plastic Surgery Hospital of Chinese Academy of Medical Sciences, No. 33, Ba-Da-Chu Road, Beijing, China.
² Ninth Department of Plastic Surgery, Plastic Surgery Hospital of Chinese Academy of Medical Sciences, No. 33, Ba-Da-Chu Road, Beijing, China. 1012980819@qq.com.

PMID: 30367294
DOI: 10.1007/s10103-018-2567-9

No abstract available

Keywords: AMSCs; Notch-1; PBMT; TGF-β1; fibrosis.

MeSH terms

Actins / metabolism
Adipose Tissue / cytology*
Animals
Apoptosis / drug effects
Cell Movement / drug effects
Cell Proliferation / drug effects
Cicatrix, Hypertrophic / metabolism
Cicatrix, Hypertrophic / pathology
Cicatrix, Hypertrophic / radiotherapy*
Culture Media, Conditioned / pharmacology
Down-Regulation*
Fibroblasts / metabolism
Fibroblasts / pathology*
Fibroblasts / radiation effects
Fibrosis
Humans
Keloid / pathology
Low-Level Light Therapy*
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells / cytology*
Mesenchymal Stem Cells / radiation effects
Phenotype
Receptors, Notch / metabolism*
Transforming Growth Factor beta1 / metabolism*

Substances

Actins
Culture Media, Conditioned
Receptors, Notch
Transforming Growth Factor beta1