Preventing Lethal Prostate Cancer with Diet, Supplements, and Rx: Heart Healthy Continues to Be Prostate Healthy and "First Do No Harm" Part I

Curr Urol Rep. 2018 Oct 27;19(12):104. doi: 10.1007/s11934-018-0846-4.


Purpose of review: To discuss the overall and latest observations of the effect of diet, lifestyle, supplements, and some prescription heart healthy medications for prostate cancer prevention.

Recent findings: The concept of maximizing heart health to prevent aggressive prostate cancer continues to be solidified with the addition of more prospective observational and randomized controlled trial data. Heart healthy is prostate healthy, but heart unhealthy is prostate unhealthy. The primary goal of reducing the risk of all-cause and cardiovascular disease (CVD) morbidity and mortality also allows for maximizing prostate cancer prevention. The obesity epidemic in children and adults along with recent diverse research has only strengthened the nexus between heart and prostate health. Greater dietary adherence toward a variety of healthy foods is associated with a graded improved probability of CVD and potentially aggressive cancer risk reduction. Preventing prostate cancer via dietary supplements should encourage a "first do no harm", or less is more approach until future evidence can reverse the concerning trend that more supplementation has resulted in either no impact or an increased risk of prostate cancer. Supplements to reduce side effects of some cancer treatments appear to have more encouraging data. Medications that improve heart health including statins, aspirin, and metformin (S.A.M.), and specific beta-blocker medications are primarily generic or low-cost and should continue to garner research interest. A watershed moment in medical education has arrived where the past perception of a diverse number of trees seemingly separated by vast distances, in reality, now appear to exist within the same forest.

Keywords: Cardiovascular disease; Diet; Prostate cancer prevention; S.A.M..

Publication types

  • Review

MeSH terms

  • Aspirin / therapeutic use
  • Cardiovascular Diseases / complications
  • Cardiovascular Diseases / prevention & control
  • Diet*
  • Dietary Supplements
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Life Style
  • Male
  • Metformin / therapeutic use
  • Obesity / complications
  • Prospective Studies
  • Prostatic Neoplasms / prevention & control*
  • Risk Reduction Behavior


  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Metformin
  • Aspirin