The complete nucleotide sequence of coxsackievirus B4 and its comparison to other members of the Picornaviridae

J Gen Virol. 1987 Jul;68 ( Pt 7):1835-48. doi: 10.1099/0022-1317-68-7-1835.


The genome of the prototype stain of coxsackievirus B4 (J.V.B. Benschoten) has been cloned in Escherichia coli and its complete nucleotide sequence determined. Excluding the poly(A) tract, the RNA genome is 7395 nucleotides in length and appears to encode a single polyprotein of 2183 amino acids. The predicted amino acid sequence of the polyprotein shows close homology (88%) to that of the previously sequenced coxsackievirus B3 and to certain regions of the polyproteins of the polioviruses and human rhinovirus 14. This allows identification of putative polyprotein cleavage signals, antigenic domains and other structural features likely to be important to the biological integrity of the virus.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Enterovirus B, Human / genetics*
  • Genes
  • Genes, Viral*
  • Picornaviridae / genetics
  • Protein Precursors / genetics
  • Protein Processing, Post-Translational
  • RNA, Viral / genetics*
  • Sequence Homology, Nucleic Acid
  • Species Specificity
  • Viral Proteins / biosynthesis
  • Viral Proteins / genetics


  • Protein Precursors
  • RNA, Viral
  • Viral Proteins

Associated data

  • GENBANK/D00149