1 Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children's Hospital Colorado and University of Colorado, Denver, CO, USA. jean.mulcahylevy@ucdenver.edu.
2 Huntsman Cancer Institute and Department of Dermatology, University of Utah, Salt Lake City, UT, USA. martin.mcmahon@hci.utah.edu.
Mutationally activated BRAFV600E influences the behavior of different types of cells in the brain and leads to promotion of seizures as well as brain tumors, indicating how both can be pharmacologically targeted in the clinic.