Sleep duration and 24-hour ambulatory blood pressure in adults not on antihypertensive medications

J Clin Hypertens (Greenwich). 2018 Dec;20(12):1712-1720. doi: 10.1111/jch.13416. Epub 2018 Oct 30.


Short sleep duration has been widely linked to increased cardiovascular morbidity and mortality. We performed a post hoc analysis of 24-hour ambulatory blood pressure monitoring (ABPM) in the Lifestyle Modification in Blood Pressure Lowering Study (LIMBS) and Penn Icelandic Sleep Apnea (PISA) Study. The 24-hour mean systolic blood pressure (BP) was 12.7 mm Hg higher in LIMBS (P < 0.001; n = 66) and 4.7 mm Hg higher in PISA (P = 0.005; n = 153) among participants with shorter sleep duration (less than 7 hours) compared to those with longer sleep duration (at least 7 hours). In multivariable adjusted models, shorter sleep duration was strongly associated with higher systolic BP on 24-hour ABPM, independent of nocturnal BP and in-office BP. There was no effect modification by obstructive sleep apnea. Adults with shorter sleep duration may benefit from screening with 24-hour ABPM to promote earlier detection of hypertension and potentially mitigate their increased risk for future cardiovascular disease.

Keywords: ambulatory; blood pressure monitoring; circadian rhythm; hypertension; obstructive sleep apnea; sleep deprivation; sleep disorders.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Blood Pressure / physiology
  • Blood Pressure Monitoring, Ambulatory / methods*
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / mortality
  • Cardiovascular Diseases / physiopathology*
  • Circadian Rhythm / physiology
  • Cross-Sectional Studies
  • Early Diagnosis
  • Female
  • Humans
  • Hypertension / diagnosis
  • Hypertension / epidemiology
  • Hypertension / physiopathology
  • Iceland / epidemiology
  • Male
  • Middle Aged
  • Prevalence
  • Risk Reduction Behavior
  • Sleep Apnea, Obstructive / complications
  • Sleep Deprivation / complications*
  • Sleep Wake Disorders / complications*