Share and share alike: the role of Tra1 from the SAGA and NuA4 coactivator complexes

Transcription. 2019 Feb;10(1):37-43. doi: 10.1080/21541264.2018.1530936. Epub 2018 Oct 30.


SAGA and NuA4 are coactivator complexes required for transcription on chromatin. Although they contain different enzymatic and biochemical activities, both contain the large Tra1 subunit. Recent electron microscopy studies have resolved the complete structure of Tra1 and its integration in SAGA/NuA4, providing important insight into Tra1 function.

Keywords: Chromatin and transcription; Eukaryotic transcription; NuA4; SAGA; Tra1; Transcription factors and co-activators; activator; coactivator; histone acetylation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Histone Acetyltransferases / chemistry
  • Histone Acetyltransferases / metabolism
  • Histone Acetyltransferases / physiology*
  • Membrane Glycoproteins / chemistry
  • Membrane Glycoproteins / metabolism
  • Membrane Glycoproteins / physiology*
  • Models, Genetic*
  • Models, Molecular
  • Saccharomyces cerevisiae Proteins / chemistry
  • Saccharomyces cerevisiae Proteins / metabolism
  • Saccharomyces cerevisiae Proteins / physiology*
  • Trans-Activators / metabolism
  • Trans-Activators / physiology
  • Transcriptional Activation


  • Membrane Glycoproteins
  • Saccharomyces cerevisiae Proteins
  • TRA1 protein, S cerevisiae
  • Trans-Activators
  • endoplasmin
  • Histone Acetyltransferases
  • NuA4 protein, S cerevisiae