Anatomic and Cellular Niches for Mycobacterium tuberculosis in Latent Tuberculosis Infection

J Infect Dis. 2019 Feb 15;219(5):685-694. doi: 10.1093/infdis/jiy579.


Latent tuberculosis has been recognized for over a century, but discovery of new niches, where Mycobacterium tuberculosis resides, continues. We evaluated literature on M.tuberculosis locations during latency, highlighting that mesenchymal and hematopoietic stem cells harbor organisms in sensitized asymptomatic individuals.

Keywords: CD34; bone marrow; hematopoietic stem cells; latent tuberculosis; mesencymal stem cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Hematopoietic Stem Cells / microbiology*
  • Humans
  • Latent Tuberculosis / microbiology*
  • Latent Tuberculosis / pathology*
  • Mesenchymal Stem Cells / microbiology*
  • Mycobacterium tuberculosis / growth & development
  • Mycobacterium tuberculosis / isolation & purification*
  • Phagocytes / microbiology*