Feasibility of extracellular volume quantification using dual-energy CT

J Cardiovasc Comput Tomogr. 2019 Jan-Feb;13(1):81-84. doi: 10.1016/j.jcct.2018.10.011. Epub 2018 Oct 22.


ObjectiveTo assess the feasibility of dual energy CT (DECT) to derive myocardial extracellular volume (ECV) and detect myocardial ECV differences without a non-contrast acquisition, compared to single energy CT (SECT). MethodsSubjects (n = 35) with focal fibrosis (n = 17), diffuse fibrosis (n = 10), and controls (n = 9) underwent non-contrast and delayed acquisitions to calculate SECT-ECV. DECT-ECV was calculated using the delayed acquisition and the derived virtual non-contrast images. In the control and diffuse fibrotic groups, the entire myocardium of the left ventricle was used to calculate ECV. Two ROIs were placed in the focal fibrotic group, one in normal and one in fibrotic myocardium. ResultsMedian ECV was 33.4% (IQR, 30.1-37.4) using SECT and 34.9% (IQR, 31.2-39.2) using DECT (p = 0.401). For both techniques, focal and diffuse fibrosis had significantly higher ECV values (all p < 0.021) than normal myocardium. There was no systematic bias between DECT and SECT (p = 0.348). SECT had a higher radiation dose (1.1 mSv difference) than DECT (p < 0.001). ConclusionECV can be measured using a DECT approach with only a delayed acquisition. The DECT approach provides similar results at a lower radiation dose compared to SECT.

Keywords: Cardiomyopathies; Dual energy CT; ECV; Fibrosis; Myocardial infarct.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Cardiomyopathies / diagnostic imaging*
  • Cardiomyopathies / pathology
  • Case-Control Studies
  • Contrast Media / administration & dosage
  • Feasibility Studies
  • Female
  • Fibrosis
  • Humans
  • Iohexol / administration & dosage
  • Iohexol / analogs & derivatives
  • Male
  • Middle Aged
  • Myocardium / pathology
  • Predictive Value of Tests
  • Radiation Dosage
  • Radiation Exposure / adverse effects
  • Radiation Exposure / prevention & control
  • Tomography, X-Ray Computed / adverse effects
  • Tomography, X-Ray Computed / methods*


  • Contrast Media
  • Iohexol
  • iopromide