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. 2018 Oct 30;11(554):eaav0917.
doi: 10.1126/scisignal.aav0917.

The RAS-ERK Pathway: A Route for Couples


The RAS-ERK Pathway: A Route for Couples

Eugenio Santos et al. Sci Signal. .


Data accumulated over more than three decades demonstrate that the assembly of macrocomplexes, mainly of dimers, is widespread among the members of the different tiers that constitute the RAS-ERK pathway. In this issue of Science Signaling, Yuan et al. report that MEK1 homodimerization is necessary for signal transduction through the RAF-ERK pathway and that cancer-related MEK1 mutations confer enhanced dimerization and resistance to MEK inhibitors. These findings endorse interference with RAS-ERK pathway-component dimerization as a potential therapeutic strategy in cancer patients.

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