CFI-400945 is not a selective cellular PLK4 inhibitor

Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10808-E10809. doi: 10.1073/pnas.1813310115. Epub 2018 Oct 30.

¹ Department of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093; koegema@ucsd.edu ashiau@ucsd.edu.
² Small Molecule Discovery Program, Ludwig Institute for Cancer Research, La Jolla, CA 92093.
³ Department of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093.
⁴ Small Molecule Discovery Program, Ludwig Institute for Cancer Research, La Jolla, CA 92093 koegema@ucsd.edu ashiau@ucsd.edu.

No abstract available

Publication types

2-(3-(4-((2,6-dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5'-methoxyspiro(cyclopropane-1,3'-indolin)-2'-one
Indazoles
Indoles
PLK4 protein, human
Protein Serine-Threonine Kinases