Survival and characteristics of pediatric salivary gland cancer: A systematic review and meta-analysis

Pediatr Blood Cancer. 2019 Mar;66(3):e27543. doi: 10.1002/pbc.27543. Epub 2018 Oct 30.


A systematic search of PubMed, EMBASE, and the Cochrane Library for studies from 2000 to 2017 including children aged 0-19 with salivary gland cancer was performed. In 19 studies, 749 children (median age of 14.2 years, female to male ratio of 1.4:1) were included; 72% had parotid tumors and 95% underwent surgery, of whom 65% had surgery alone and 24% with adjuvant radiotherapy. Low-grade and stage mucoepidermoid carcinoma were the most frequent cancer. The 5-year overall- and disease-free survival was 94% and 83%. Recurrence was observed in 20% at a median of 1.1 years from diagnosis.

Keywords: meta-analysis; pediatric; salivary gland cancer; systematic review.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Combined Modality Therapy
  • Humans
  • Prognosis
  • Salivary Gland Neoplasms / mortality*
  • Salivary Gland Neoplasms / pathology*
  • Salivary Gland Neoplasms / therapy
  • Survival Rate