[Recent Advances in the Application of Headspace Gas Chromatography-Mass Spectrometry]

Se Pu. 2018 Oct 8;36(10):962-971. doi: 10.3724/SP.J.1123.2018.05013.
[Article in Chinese]


As a sample preparation technique without extraction by organic solvent, headspace analysis is usually combined with gas chromatography-mass spectrometry (GC-MS) to analyze volatile organic compounds in complex matrices. Headspace gas chromatography-mass spectrometry (HS-GC-MS) is a fast, efficient, green, and sensitive technique, and thus it plays an important role in routine analysis. A brief overview of static headspace, dynamic headspace, headspace solid-phase microextraction and GC-MS is provided, followed by the impact of the analysis system and the optimization process. According to the matrix type classification, the application of HS-GC-MS in the analysis of food samples, environment samples, biology samples, etc. is reviewed. This report clearly indicates that the ongoing research on HS-GC-MS is active and new applications are emerging. It has significant prospects for the analysis of volatile organic compounds.

Keywords: dynamic headspace (D-HS); gas chromatography-mass spectrometry (GC-MS); headspace solid-phase microextraction (HS-SPME); review; static headspace (S-HS); volatile organic compounds (VOCs).

Publication types

  • Review

MeSH terms

  • Gas Chromatography-Mass Spectrometry*
  • Solid Phase Microextraction*
  • Volatile Organic Compounds / analysis*


  • Volatile Organic Compounds