Possible correction of defective polymorphonuclear cell functions in type-2 diabetes mellitus by met-enkephalin

Ann N Y Acad Sci. 1987:496:166-9. doi: 10.1111/j.1749-6632.1987.tb35761.x.


In vitro pretreatment with Met-Enk of human PMNLs obtained from patients suffering from type-2 diabetes mellitus resulted in the normalization of the ROS generating system. It is assumed that Met-Enk has a modulating effect on the arachidonic acid metabolism, with a consecutive increase of the LTB4 release.

Publication types

  • Comparative Study

MeSH terms

  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / immunology*
  • Enkephalin, Methionine / pharmacology*
  • Humans
  • In Vitro Techniques
  • Neutrophils / drug effects
  • Neutrophils / immunology*
  • Neutrophils / physiology
  • Reference Values
  • Superoxides / blood


  • Superoxides
  • Enkephalin, Methionine