Abstract
In vitro pretreatment with Met-Enk of human PMNLs obtained from patients suffering from type-2 diabetes mellitus resulted in the normalization of the ROS generating system. It is assumed that Met-Enk has a modulating effect on the arachidonic acid metabolism, with a consecutive increase of the LTB4 release.
MeSH terms
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Diabetes Mellitus, Type 2 / blood
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Diabetes Mellitus, Type 2 / immunology*
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Enkephalin, Methionine / pharmacology*
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Humans
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In Vitro Techniques
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Neutrophils / drug effects
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Neutrophils / immunology*
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Neutrophils / physiology
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Reference Values
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Superoxides / blood
Substances
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Superoxides
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Enkephalin, Methionine