[Reaction Development Utilizing the Features of Chemical Elements and Synthesis of Marine Natural Products]

Yakugaku Zasshi. 2018;138(11):1335-1344. doi: 10.1248/yakushi.18-00126.
[Article in Japanese]

Abstract

Marine natural products and biologically active compounds often contain cyclic ether units. Thus, regio- and stereoselective construction of these structures has long been a topic of interest in organic synthesis. This review summarizes new synthetic approaches to polycyclic ether natural products utilizing the features of chemical elements.

Keywords: 1,3-transposition; gold catalysis; maitotoxin; polyether; rhenium catalysis.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Products / chemical synthesis*
  • Biological Products / chemistry
  • Catalysis
  • Chemistry, Organic / methods
  • Elements*
  • Ethers, Cyclic / chemical synthesis*
  • Ethers, Cyclic / chemistry
  • Gold
  • Hydrophobic and Hydrophilic Interactions
  • Marine Biology*
  • Marine Toxins / chemical synthesis*
  • Marine Toxins / chemistry
  • Mice
  • Molecular Conformation
  • Organic Chemistry Phenomena
  • Oxocins / chemical synthesis*
  • Oxocins / chemistry
  • Rhenium / chemistry
  • Stereoisomerism

Substances

  • Biological Products
  • Elements
  • Ethers, Cyclic
  • Marine Toxins
  • Oxocins
  • Rhenium
  • Gold
  • maitotoxin