Formation of Neoarteries with Optimal Remodeling Using Rapidly Degrading Textile Vascular Grafts

Tissue Eng Part A. 2019 Apr;25(7-8):632-641. doi: 10.1089/ten.TEA.2018.0167. Epub 2019 Jan 7.

Abstract

We utilized innovative textile technology to create tissue-engineered vascular grafts (TEVGs) comprised exclusively of rapidly degrading material poly(glycolic acid). Our new technology led to robust neotissue formation in the TEVGs, especially extracellular matrix formation, such as elastin. In addition, the rapid degradation of the polymer significantly reduced complications, such as stenosis or calcification, as seen with the use of slow degrading polymers in the majority of previous studies for aortic small diameter TEVGs.

Keywords: neoartery; rapidly degrading; textile; tissue engineered vascular grafts.

MeSH terms

  • Animals
  • Blood Vessel Prosthesis Implantation / methods
  • Constriction, Pathologic / surgery
  • Polymers / chemistry
  • Tissue Engineering / methods*

Substances

  • Polymers