Optical coherence tomography angiography (OCTA) is a non-invasive retinal imaging innovation that has been gaining popularity for the evaluation of the retinal vasculature. Of clinical importance is its current use either as an alternative or in conjunction with conventional dye-based angiography in neovascular age-related macular degeneration. OCTA is not without limitations and these include image artefact, a relatively small field of view and failure of the segmentation algorithms, which can confound the interpretation of findings. While there are numerous publications on OCTA in neovascular AMD, few have examined the diagnostic accuracy of this new technology compared with the accepted gold standard of fundus fluorescein angiography (FFA). In this review, we summarise the literature on the clinical application of OCTA in nAMD. In particular, we have reviewed the published articles that have reported the sensitivity and specificity of OCTA in the diagnosis of nAMD, and those that have described and or correlated the morphological findings and compared them to dye-based angiography.
摘要: 光学相干断层扫描血管造影 (OCTA) 是一种无创、新型的视网膜成像技术, 在视网膜血管性疾病的评估方面应用得越来越广泛。其临床重要性在于, 目前可替代作为新生血管性年龄相关性黄斑变性 (nAMD) 常规检查的血管造影或与常规血管造影相补充。 OCTA 也有其局限性, 如图像伪影、观察范围有限以及分割算法的失误, 由此可能会影响对结果解释的准确性。目前有大量关于OCTA在nAMD诊断中应用的文献报道, 但很少有人将这种新技术与公认的金标准眼底荧光血管造影 (FFA) 在诊断的准确性方面进行对比。在这篇综述中, 我们总结了 OCTA 在 nAMD 诊疗中的临床应用, 特别是总结了OCTA 在 nAMD 诊断中的敏感性和特异性以及形态学改变与常规 FFA 发现的相关性。.