Comparison of platelet-rich plasma vs hyaluronic acid injections in patients with knee osteoarthritis: A protocol for a systematic review and meta-analysis

Medicine (Baltimore). 2018 Nov;97(44):e13049. doi: 10.1097/MD.0000000000013049.


Background: Knee osteoarthritis (KOA) is a progressive joint disease involving intraarticular and periarticular structures. In recent years, there has been increasing interest in the use of autologous growth factors, such as intraarticular injections of platelet-rich plasma (PRP), to treat KOA. It is necessary to update the research and reevaluate the efficacy and safety of PRP to provide up-to-date evidence for KOA management. Therefore, we provide a protocol for a systematic review of PRP for KOA.

Methods: The aim of this study was to retrieve papers on the topic of PRP treatment for KOA in electronic databases including PubMed, Embase, and the Cochrane Library. The search will include studies that were published from the time the databases were established until April 2018. The entire process will include study selection, data extraction, risk of bias assessment, and meta-analyses.

Results: The literature will provide a high-quality analysis of the current evidence supporting PRP for KOA based on various comprehensive assessments including the Western Ontario and McMaster Universities Osteoarthritis Index, visual analog scale scores, International Knee Documentation Committee scores, Lequesne index scores, and adverse events.

Conclusion: This proposed systematic review will provide up-to-date evidence to assess the effect of PRP treatment for patients with KOA.

Prospero registration number: CRD42018108825.

Publication types

  • Meta-Analysis

MeSH terms

  • Female
  • Humans
  • Hyaluronic Acid / administration & dosage*
  • Injections, Intra-Articular
  • Knee Joint / pathology
  • Male
  • Osteoarthritis, Knee / therapy*
  • Pain Measurement
  • Platelet-Rich Plasma / drug effects*
  • Systematic Reviews as Topic
  • Treatment Outcome


  • Hyaluronic Acid