Association between family history of mental disorders and outcome in psychotic disorders

Psychiatry Res. 2018 Dec;270:616-621. doi: 10.1016/j.psychres.2018.10.047. Epub 2018 Oct 22.


We investigated the association of family history of mental disorders, especially psychosis, with occupational and clinical outcome in psychotic disorders in a longitudinal population-based cohort. The Northern Finland Birth Cohort 1986 (n = 9432) was used to gather the data. In total 189 individuals with psychosis were identified by age of 28. The outcome was assessed by using register information regarding occupational activity, disability pension and hospital treatments due to psychiatric cause. Parental psychosis and any psychiatric disorder were used as predictors of outcome. The results showed that presence of any parental psychiatric disorder was associated with higher number of days spent at hospital and higher number of hospitalizations in psychotic disorders, but was not associated with occupational outcome or disability pension. The presence of parental psychosis was not associated with outcome. These findings suggest that the presence of any psychiatric disorder among parents may increase the risk of poorer outcome in psychoses in terms of need of hospitalisations. Based on this study the presence of parental psychosis is not associated with outcome, but the result should be interpreted with caution due to the small sample size and conflict with the results of earlier studies.

Keywords: Heritability; Prognosis; Schizophrenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cohort Studies
  • Female
  • Finland
  • Genetic Predisposition to Disease / genetics
  • Hospitalization / statistics & numerical data
  • Humans
  • Longitudinal Studies
  • Male
  • Mental Disorders / diagnosis
  • Mental Disorders / genetics*
  • Mental Disorders / psychology
  • Mental Disorders / therapy
  • Psychotic Disorders / diagnosis
  • Psychotic Disorders / genetics*
  • Psychotic Disorders / psychology
  • Psychotic Disorders / therapy
  • Registries
  • Schizophrenia / diagnosis
  • Schizophrenia / genetics*
  • Schizophrenia / therapy
  • Schizophrenic Psychology*
  • Treatment Outcome