Alpha-thalassemia in Saudi Arabia: deletion pattern

Hum Genet. 1987 Jun;76(2):196-8. doi: 10.1007/BF00284921.

Abstract

Alpha-Thalassemia exists at a high prevalence in several regions of Saudi Arabia. The restriction endonucleases BamHI and BglII were used to investigate the molecular basis of deletion type of alpha-thalassemia in 226 subjects from the eastern and 61 subjects from the northwestern regions of the country. The arrangements -alpha/alpha alpha and -alpha/-alpha were common. BglII digestion revealed the existence of rightward deletion in a majority of the cases. Leftward deletions, both homozygous and heterozygous, were also identified. Triple alpha-gene arrangements alpha alpha alpha anti 3.7/ were observed at a low frequency in both regions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins*
  • Chromosome Deletion*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 16
  • DNA Restriction Enzymes
  • Deoxyribonuclease BamHI
  • Deoxyribonucleases, Type II Site-Specific*
  • Globins / genetics*
  • Humans
  • Saudi Arabia
  • Thalassemia / epidemiology
  • Thalassemia / genetics*

Substances

  • Bacterial Proteins
  • Globins
  • DNA Restriction Enzymes
  • Deoxyribonuclease BamHI
  • BglII endonuclease
  • Deoxyribonucleases, Type II Site-Specific