Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment

ACS Nano. 2018 Nov 27;12(11):10582-10620. doi: 10.1021/acsnano.8b04758. Epub 2018 Nov 12.


Graphene and its derivatives are heralded as "miracle" materials with manifold applications in different sectors of society from electronics to energy storage to medicine. The increasing exploitation of graphene-based materials (GBMs) necessitates a comprehensive evaluation of the potential impact of these materials on human health and the environment. Here, we discuss synthesis and characterization of GBMs as well as human and environmental hazard assessment of GBMs using in vitro and in vivo model systems with the aim to understand the properties that underlie the biological effects of these materials; not all GBMs are alike, and it is essential that we disentangle the structure-activity relationships for this class of materials.

Keywords: carbon nanomaterials; environment; exposure; graphene; hazard; life cycle assessment; safety; toxicity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Environmental Monitoring*
  • Graphite / adverse effects*
  • Graphite / chemistry
  • Health*
  • Humans
  • Materials Testing
  • Nanostructures / adverse effects*
  • Nanostructures / chemistry*
  • Risk Assessment
  • Structure-Activity Relationship


  • Graphite