20 Years of Human Pluripotent Stem Cell Research: It All Started with Five Lines

Cell Stem Cell. 2018 Nov 1;23(5):644-648. doi: 10.1016/j.stem.2018.10.009.


November 2018 marks the 20th anniversary of the seminal human embryonic stem cell (hESC) publication, which reported the initial hESC derivations and launched the field of human pluripotent stem cell research. To commemorate this significant milestone, we reflect on the scientific, economic, and clinically relevant impact of this groundbreaking achievement.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Pluripotent Stem Cells / cytology*
  • Stem Cell Research / history*