Interleukins as modulators of angiogenesis and anti-angiogenesis in tumors

Domenico Ribatti

doi:10.1016/j.cyto.2018.10.022

Interleukins as modulators of angiogenesis and anti-angiogenesis in tumors

Cytokine. 2019 Jun:118:3-7. doi: 10.1016/j.cyto.2018.10.022. Epub 2018 Oct 31.

Author

Domenico Ribatti¹

Affiliation

¹ Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy. Electronic address: domenico.ribatti@uniba.it.

PMID: 30389232
DOI: 10.1016/j.cyto.2018.10.022

Abstract

Interleukins (ILs) are secreted by leukocytes and macrophages and are involved in communication amongst leukocytes regulating numerous biological processes and immune responses. This review article analyzes the role played by ILs in the regulation of angiogenesis and anti-angiogenesis in both solid and hematological tumors.

Keywords: Angiogenesis; Anti-angiogenesis; Interleukins; Tumor growth.

Publication types

Review

MeSH terms

Animals
Humans
Interleukins / immunology*
Leukocytes / immunology
Macrophages / immunology
Neoplasms / immunology*
Neovascularization, Pathologic / immunology*

Substances

Interleukins