Structure and variability of the a sequence in the genome of human cytomegalovirus (Towne strain)

J Gen Virol. 1987 Aug;68 ( Pt 8):2223-30. doi: 10.1099/0022-1317-68-8-2223.


We have defined the boundaries of the a sequence from human cytomegalovirus (CMV) strain Towne, characterized internal variability and determined the position of the cleavage site used to generate genomic termini. The cleavage site is positioned a fixed distance from two stretches of sequence homology that have been observed near the ends of many herpesvirus genomes. Unlike a comparable region in CMV (AD169), the CMV (Towne) a sequence has a relatively low level of variability within the a sequence and its structure is stable through repeated virus passage.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Cloning, Molecular
  • Cytomegalovirus / genetics*
  • DNA Restriction Enzymes
  • Genes, Viral*
  • Genetic Variation*
  • Humans


  • DNA Restriction Enzymes

Associated data

  • GENBANK/D00147
  • GENBANK/D00148