Signs and Symptoms of Hypoparathyroidism

Endocrinol Metab Clin North Am. 2018 Dec;47(4):759-770. doi: 10.1016/j.ecl.2018.07.001.


Hypoparathyroidism is associated with a spectrum of clinical manifestations in the acute and chronic settings, from mild to debilitating. Although the acute symptoms of hypocalcemia are primarily due to neuromuscular irritability, the chronic manifestations of hypoparathyroidism may be due to the disease itself or to complications of therapy or to both. The chronic complications of hypoparathyroidism can affect multiple organ systems, including the renal, neurologic, neuropsychiatric, skeletal, and immune systems. Further research is needed to determine the pathophysiology of complications in hypoparathyroidism and whether interventions can decrease the risk of these complications.

Keywords: Basal ganglia calcification; Cataract; Complication; Hypoparathyroidism; Renal failure.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Calcinosis / etiology
  • Humans
  • Hypocalcemia / etiology
  • Hypoparathyroidism / complications*
  • Hypoparathyroidism / diagnosis*
  • Hypoparathyroidism / therapy