Non-coding RNA Neat1 and Abhd11os expressions are dysregulated in medium spiny neurons of Huntington disease model mice

Neurosci Res. 2019 Oct:147:58-63. doi: 10.1016/j.neures.2018.10.013. Epub 2018 Nov 2.


Huntington Disease (HD) is a neurodegenerative disorder caused by expanded CAG repeats in the exon1 of huntingtin gene (HTT). The mutant HTT affects the transcriptional profile of neurons by disrupting the activities of transcriptional machinery and alters expression of many genes. In this study, we identified dysregulated non-coding RNAs (ncRNAs) in medium spiny neurons of 4-week-old HD model mouse. Also, we observed the intracellular localizations of Abhd11os and Neat1 ncRNAs by ViewRNA in situ hybridization, which could provide more precise detection, suggesting that it is a useful method to investigate the expression changes of genes with low expression levels.

Keywords: Abhd11os; Gene expression; Huntington disease; Microarray; Neat1; Non-coding RNA; ViewRNA in situ hybridization.

MeSH terms

  • Animals
  • Brain / metabolism
  • Corpus Striatum / metabolism
  • Disease Models, Animal
  • Dopamine and cAMP-Regulated Phosphoprotein 32 / metabolism
  • Gene Expression
  • Humans
  • Huntington Disease / genetics
  • Huntington Disease / metabolism*
  • Huntington Disease / pathology
  • In Situ Hybridization
  • Mice
  • Mice, Transgenic
  • Neurons / metabolism*
  • Neurons / pathology
  • RNA, Long Noncoding / biosynthesis*
  • RNA, Long Noncoding / genetics
  • RNA, Long Noncoding / metabolism
  • Serine Proteases / biosynthesis*
  • Serine Proteases / genetics
  • Serine Proteases / metabolism
  • Transcriptome


  • Dopamine and cAMP-Regulated Phosphoprotein 32
  • NEAT1 long non-coding RNA, mouse
  • Ppp1r1b protein, mouse
  • RNA, Long Noncoding
  • Serine Proteases