Detection of gastrin-releasing peptide mRNA in small cell lung carcinomas and medullary thyroid carcinomas using synthetic oligodeoxyribonucleotide probes

Jpn J Clin Oncol. 1987 Jun;17(2):157-63.


Human gastrin-releasing peptide (GRP) mRNA was detected in the tumor tissues of medullary thyroid carcinomas and small cell lung carcinomas using synthetic oligodeoxyribonucleotides as hybridization probes. The amount of GRP mRNA was estimated by radiodensitometric hybridization assay. A good correlation was found between the amount of GRP mRNA and the concentration of immunoreactive GRP in the tumor tissues.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma / analysis*
  • Carcinoma, Small Cell / analysis*
  • Densitometry
  • Gastrin-Releasing Peptide
  • Gastrins / analysis*
  • Gastrins / immunology
  • Humans
  • Immunologic Techniques
  • Lung Neoplasms / analysis*
  • Nucleic Acid Hybridization
  • Oligodeoxyribonucleotides* / chemical synthesis
  • Peptides / analysis*
  • Peptides / immunology
  • RNA, Messenger / analysis*
  • Radioimmunoassay
  • Thyroid Neoplasms / analysis*


  • Gastrins
  • Oligodeoxyribonucleotides
  • Peptides
  • RNA, Messenger
  • Gastrin-Releasing Peptide