Tissue regeneration: Impact of sleep on stem cell regenerative capacity

Life Sci. 2018 Dec 1;214:51-61. doi: 10.1016/j.lfs.2018.10.057. Epub 2018 Oct 28.


The circadian rhythm orchestrates many cellular functions, such as cell division, cell migration, metabolism and numerous intracellular biological processes. The physiological changes during sleep are believed to promote a suitable microenvironment for stem cells to proliferate, migrate and differentiate. These effects are mediated either directly by circadian clock genes or indirectly via hormones and cytokines. Hormones, such as melatonin and cortisol, are secreted in response to neural optic signals and act in harmony to regulate many biological functions during sleep. Herein, we correlate the effects of the main circadian genes on the expression of certain stem cell genes responsible for the regeneration of different tissues, including bone, cartilage, skin, and intestine. We also review the effects of different hormones and cytokines on stem cell activation or suppression and their relationship to the day/night cycle. The correlation of circadian rhythm with tissue regeneration could have implications in understanding the biology of sleep and tissue regeneration and in enhancing the efficacy and timing of surgical procedures.

Keywords: Circadian rhythm; Differentiation; Regeneration; Sleep; Stem cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Pressure / physiology
  • Body Temperature
  • Cell Differentiation / physiology
  • Cell Proliferation / genetics
  • Circadian Rhythm / physiology*
  • Embryonic Stem Cells / physiology
  • Gene Expression Regulation
  • Hormones / physiology
  • Humans
  • Regeneration / physiology*
  • Sleep / physiology*
  • Stem Cells / physiology*


  • Hormones