Depression

Gin S Malhi; J John Mann

doi:10.1016/S0140-6736(18)31948-2

Depression

Lancet. 2018 Nov 24;392(10161):2299-2312. doi: 10.1016/S0140-6736(18)31948-2. Epub 2018 Nov 2.

Authors

Gin S Malhi¹, J John Mann²

Affiliations

¹ Department of Academic Psychiatry, Sydney Medical School Northern, University of Sydney, Sydney, NSW, Australia; CADE Clinic, Royal North Shore Hospital, Sydney, NSW, Australia. Electronic address: gin.malhi@sydney.edu.au.
² Molecular Imaging and Neuropathology Division, Department of Psychiatry, Columbia University, New York, NY, USA.

PMID: 30396512
DOI: 10.1016/S0140-6736(18)31948-2

Abstract

Major depression is a common illness that severely limits psychosocial functioning and diminishes quality of life. In 2008, WHO ranked major depression as the third cause of burden of disease worldwide and projected that the disease will rank first by 2030.¹ In practice, its detection, diagnosis, and management often pose challenges for clinicians because of its various presentations, unpredictable course and prognosis, and variable response to treatment.

Publication types

Review

MeSH terms

Adolescent
Adult
Aged
Brain-Derived Neurotrophic Factor / metabolism
Cost of Illness
Depression / diagnosis
Depression / epidemiology*
Depression / psychology*
Depression / therapy
Depressive Disorder, Major / diagnosis
Depressive Disorder, Major / psychology*
Depressive Disorder, Major / therapy
Diagnostic and Statistical Manual of Mental Disorders
Female
Humans
Hydrocortisone / blood
Hypothalamo-Hypophyseal System / physiopathology
Male
Middle Aged
Neuronal Plasticity / physiology
Prevalence
Prognosis
Quality of Life / psychology
Young Adult

Substances

Brain-Derived Neurotrophic Factor
Hydrocortisone