Terror in the dirt: Sensory determinants of host seeking in soil-transmitted mammalian-parasitic nematodes

Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):496-510. doi: 10.1016/j.ijpddr.2018.10.008. Epub 2018 Oct 26.

Abstract

Infection with gastrointestinal parasitic nematodes is a major cause of chronic morbidity and economic burden around the world, particularly in low-resource settings. Some parasitic nematode species, including the human-parasitic threadworm Strongyloides stercoralis and human-parasitic hookworms in the genera Ancylostoma and Necator, feature a soil-dwelling infective larval stage that seeks out hosts for infection using a variety of host-emitted sensory cues. Here, we review our current understanding of the behavioral responses of soil-dwelling infective larvae to host-emitted sensory cues, and the molecular and cellular mechanisms that mediate these responses. We also discuss the development of methods for transgenesis and CRISPR/Cas9-mediated targeted mutagenesis in Strongyloides stercoralis and the closely related rat parasite Strongyloides ratti. These methods have established S. stercoralis and S. ratti as genetic model systems for gastrointestinal parasitic nematodes and are enabling more detailed investigations into the neural mechanisms that underlie the sensory-driven behaviors of this medically and economically important class of parasites.

Keywords: Chemosensation; Host seeking; Parasitic helminth; Parasitic nematode; Sensory behavior; Strongyloides; Thermosensation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Ancylostoma / physiology
  • Ancylostomiasis / parasitology
  • Ancylostomiasis / transmission
  • Animals
  • Gastrointestinal Diseases / parasitology
  • Host-Parasite Interactions*
  • Humans
  • Larva / physiology
  • Necator / physiology
  • Nematoda / physiology*
  • Nematode Infections / parasitology
  • Nematode Infections / transmission*
  • Rats
  • Sensation*
  • Soil / parasitology*
  • Strongyloides ratti / physiology
  • Strongyloides stercoralis / physiology

Substances

  • Soil