Syringocystadenoma Papilliferum of the Anogenital Area and Buttocks: A Report of 16 Cases, Including Human Papillomavirus Analysis and HRAS and BRAF V600 Mutation Studies

Am J Dermatopathol. 2019 Apr;41(4):281-285. doi: 10.1097/DAD.0000000000001285.


Syringocystadenoma papilliferum (SCAP) is a benign tumor most commonly located on the head and neck area often associated with nevus sebaceus. In its usual location, the human papillomavirus (HPV) DNA and mutations in the RAS/mitogen-activated protein kinase signaling pathway have been detected in SCAP. We studied 16 cases of SCAP in the anogenital areas and buttock where this neoplasm is rare and attempted to find out whether SCAP in these sites have different histopathological and molecular biological features. It seems that there is no significant difference between the morphology of anogenital SCAP and SCAP in other locations. Several tumors in our cohort demonstrated features resembling those seen in warts, but HPV DNA was not found in these lesions. On the contrary, we identified DNA of HPV high-risk types in some tumors without HPV-related morphology. Our study confirms the role of HRAS and BRAF V600 mutations in the pathogenesis of SCAP, including SCAP in the anogenital areas and buttock.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anal Canal / pathology
  • Buttocks / pathology
  • Female
  • Genital Neoplasms, Female / genetics
  • Genital Neoplasms, Female / pathology
  • Genital Neoplasms, Female / virology
  • Genital Neoplasms, Male / genetics
  • Genital Neoplasms, Male / pathology
  • Humans
  • Male
  • Middle Aged
  • Mutation
  • Papillomaviridae
  • Papillomavirus Infections / epidemiology*
  • Proto-Oncogene Proteins B-raf / genetics*
  • Proto-Oncogene Proteins p21(ras) / genetics*
  • Sweat Gland Neoplasms / genetics*
  • Sweat Gland Neoplasms / pathology
  • Sweat Gland Neoplasms / virology
  • Tubular Sweat Gland Adenomas / genetics*
  • Tubular Sweat Gland Adenomas / pathology*
  • Tubular Sweat Gland Adenomas / virology
  • Young Adult


  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf
  • HRAS protein, human
  • Proto-Oncogene Proteins p21(ras)