Loss of nerve growth factor receptors in sympathetic ganglia from aged mice

Biochem Biophys Res Commun. 1987 Jul 31;146(2):797-801. doi: 10.1016/0006-291x(87)90600-0.

Abstract

[125I]-Nerve growth factor (NGF) binding was studied in superior cervical ganglia from mice 4-7 months and 24-27 months of age. Scatchard analysis demonstrated losses of both high and low affinity components of NGF receptor. These results indicate loss of NGF receptors may lead to the diminished responsiveness to NGF in aged sympathetic ganglion neurons.

MeSH terms

  • Aging*
  • Animals
  • Ganglia, Sympathetic / metabolism*
  • Kinetics
  • Mice
  • Nerve Growth Factors / metabolism
  • Receptors, Cell Surface / metabolism*
  • Receptors, Nerve Growth Factor

Substances

  • Nerve Growth Factors
  • Receptors, Cell Surface
  • Receptors, Nerve Growth Factor