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Randomized Controlled Trial
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Effects of 4-Week Creatine Supplementation Combined With Complex Training on Muscle Damage and Sport Performance

Randomized Controlled Trial

Effects of 4-Week Creatine Supplementation Combined With Complex Training on Muscle Damage and Sport Performance

Chia-Chi Wang et al. Nutrients.


Creatine supplementation has an ergogenic effect in an acute complex training bout, but the benefits of chronic creatine supplementation during long-term complex training remain unknown. The study aimed to evaluate the effects of 4-week complex training combined with creatine supplementation on sport performances and muscle damage biomarkers. Thirty explosive athletes were assigned to the creatine or placebo group, which consumed 20 g of creatine or carboxymethyl cellulose, respectively, per day for 6 days followed by 2 g of the supplements until the end of the study. After 6 days of supplementation, subjects performed tests of one repetition maximum (1-RM) strength of half squat and complex training bouts to determine the optimal individual post-activation potentiation time. Thereafter, all subjects performed a complex training programme consisting of six sets of 5-RM half squats and plyometric jumps 3 times per week for 4 weeks. Body composition, 30-m sprint and jump performances were assessed before and after the training period. Moreover, blood creatine kinase (CK) activity was analysed at the first and the last training bout. After the training, the 1-RM strength in the creatine group was significantly greater than in the placebo group (p < 0.05). CK activity after the complex training bout in the creatine group was significantly reduced compared with the placebo group (p < 0.05). No differences were noted for other variables. This study concluded that creatine supplementation combined with complex training improved maximal muscular strength and reduced muscle damage during training.

Keywords: creatine kinase; half squat; optimal individual post-activation potentiation time; plyometric jump.

Conflict of interest statement

The authors declare no conflicts of interest.


Figure 1
Figure 1
Creatine kinase activity in the creatine and placebo groups after (A) the first and (B) last training bouts. All values after training were significantly increased compared with pre-training values in both groups (p < 0.05). * Indicates a significant difference (p < 0.05) from the placebo group at the same time point.

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    1. Cooper R., Naclerio F., Allgrove J., Jimenez A. Creatine supplementation with specific view to exercise/sports performance: An update. J. Int. Soc. Sports Nutr. 2012;9:33. doi: 10.1186/1550-2783-9-33. - DOI - PMC - PubMed
    1. Volek J.S., Ratamess N.A., Rubin M.R., Gomez A.L., French D.N., McGuigan M.M., Scheett T.P., Sharman M.J., Hakkinen K., Kraemer W.J. The effects of creatine supplementation on muscular performance and body composition responses to short-term resistance training overreaching. Eur. J. Appl. Physiol. 2004;91:628–637. doi: 10.1007/s00421-003-1031-z. - DOI - PubMed
    1. Freitas T.T., Martinez-Rodriguez A., Calleja-Gonzalez J., Alcaraz P.E. Short-term adaptations following complex training in team-sports: A meta-analysis. PLoS ONE. 2017;12:e0180223 doi: 10.1371/journal.pone.0180223. - DOI - PMC - PubMed
    1. Docherty D., Robbins D., Hodgson M. Complex training revisited: A review of its current status as a viable training approach. Strength Cond. J. 2004;26:52–57. doi: 10.1519/00126548-200412000-00011. - DOI
    1. Lorenz D. Postactivation potentiation: An introduction. Int. J. Sports Phys. Ther. 2011;6:234–240. - PMC - PubMed

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