Vitamin E intake and risk of stroke: a meta-analysis

Br J Nutr. 2018 Nov;120(10):1181-1188. doi: 10.1017/S0007114518002647.


Findings from observational studies on the associations between vitamin E intake and stroke risk remain controversial, and the dose-response relationship between vitamin E intake and risk of stroke remains to be determined. We conducted a meta-analysis of prospective studies aiming to clarify the relationships between vitamin E intake and risk of stroke. Relevant studies were identified by searching online databases through to June 2018. We computed summary relative risks (RR) with corresponding 95 % CI. Among 3156 articles retrieved from online databases and relevant bibliographies, nine studies involving 3284 events and 220 371 participants were included in the final analyses. High dietary vitamin E intake was inversely associated with the risk of overall stroke (RR=0·83, 95 % CI 0·73, 0·94), and with the risk of stroke for individuals who were followed-up for <10 (RR=0·84, 95 % CI 0·72, 0·91). There was a non-linear association between dietary vitamin E intake and stroke risk (P=0·0249). Omission of any single study did not alter the summary result. In conclusion, this meta-analysis suggests that there is a significant inverse relationship between dietary vitamin E intake and stroke risk. This meta-analysis provides evidence that a higher dietary vitamin E intake is associated with a lower stroke risk.

Keywords: RCT; RR; randomised controlled trial; relative risk; Dose–response relationships; Meta-analyses; Stroke risk; Vitamin E intake.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Body Mass Index
  • Diet*
  • Dietary Supplements
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nonlinear Dynamics
  • Nutritional Status
  • Observational Studies as Topic
  • Prospective Studies
  • Risk Factors
  • Stroke / prevention & control*
  • Vitamin E / administration & dosage*


  • Vitamin E