DNA methylation is an important epigenetic barrier during somatic cell reprogramming. Yet, how genome-wide methylation is reprogrammed remains largely unknown. Sardina et al. (Cell Stem Cell 2018:https://doi.org/10.1016/j.stem.2018.08.016) address this question by mapping the DNA methylomes of cells undergoing reprogramming and show that TET proteins and transcription factors cooperate to orchestrate demethylation critical to reprogramming.
Keywords: DNA methylation; TET protein; somatic cell reprogramming.
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