Radical Addition/Cyclization Reaction of 2-Vinylanilines with Alkynes: Synthesis of Naphthalenes via Electron Catalysis

Xia Cao; Bao-Gui Cai; Guo-Yong Xu; Jun Xuan

doi:10.1002/asia.201801496

Radical Addition/Cyclization Reaction of 2-Vinylanilines with Alkynes: Synthesis of Naphthalenes via Electron Catalysis

Chem Asian J. 2018 Dec 18;13(24):3855-3858. doi: 10.1002/asia.201801496. Epub 2018 Nov 21.

Authors

Xia Cao¹, Bao-Gui Cai¹, Guo-Yong Xu², Jun Xuan^{1

2}

Affiliations

¹ Department of Chemistry and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Anhui University, Hefei, Anhui, 230601, China.
² Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui, 230601, China.

PMID: 30402899
DOI: 10.1002/asia.201801496

Abstract

A cascade radical addition/cyclization reaction of 2-vinylanilines with alkynes for the synthesis of biologically important naphthalene derivatives is reported. In this transformation, the in-situ-formed diazonium salts from 2-vinylanilines served as efficient aryl radical precursors and the reaction was run under metal-free conditions.

Keywords: diazonium salts; electron catalysis; metal free; naphthalene compounds; radical cyclization.

Abstract

Grants and funding